Read this first
This pathway is newer than the rest. Its structure, its safety rules and the targets it sets you were written and signed by a clinician, and the weekly reading is built from published research with every claim numbered to the paper it came from. Nothing here sets or changes a medication: that conversation is with your prescriber, and your Whole Health Coach helps you prepare for it. If something reads wrong to you, tell your Whole Health Coach. We would rather hear it than not.
Who this is for
Adults currently taking semaglutide, liraglutide or tirzepatide for weight management, at any point in titration or at a maintenance dose. Source of the prescription does not gate entry: telehealth and compounded supply are in scope, and establishing a continuity clinician becomes a named task in module 1 rather than a condition of enrolling. We ask who prescribes it, because every safety step in this pathway ends with contacting them, but not having one does not stop you enrolling. If you take insulin or a sulfonylurea, your Whole Health Coach confirms your prescriber knows you are here before you start: eating less on this medication raises the risk of a low, and the two effects add up. Members who have already stopped belong in GLP-1 Maintenance, which is not built yet.
What brings people here
Member reports current use of a GLP-1 receptor agonist or GLP-1/GIP co-agonist for weight management on the Whole Health quiz (item I5), or tells someone on their care team they have started one. Members already in Weight Loss who begin a medication move here rather than running both.
Clinical framework
OneVillage-developed; no clinician playbook.
How the 8 weeks run
Baseline assessments, your first SMART goal, and the 1:1 that sets up everything after it.
Specialists and clinicians rotate in, and sessions come thickest here. One change at a time, in the domains your baseline flagged.
Re-score, refresh the care plan, and check in 1:1 on what is and is not working.
The remaining domains, at a lighter cadence, and the work of making the early weeks hold under pressure.
Final re-score, relapse prevention, and the plan for what happens next.
When your sessions fall
The program is built in four-week modules. Sessions come thickest at the start, when what you decide matters most, and step down as things settle. That is 5 sessions of 45 minutes across 8 weeks, counting the visit before week 1.
| Module | Weeks | Sessions | Cadence |
|---|---|---|---|
| Module 1 | Weeks 1 to 4 | 2 | every other week |
| Module 2 | Weeks 5 to 8 | 2 | every other week |
Week by week
- Before you beginBefore you begin
Your pathway starts with a 45-minute visit with Cindy Cathcart, your Whole Health Coach. Before it, read week 0 and complete your baseline questionnaires: the mood screens, a three-day record of what you ate, and the three function measures we will repeat at weeks 4 and 8. Week 0 also says plainly what this pathway promises and what it does not, and it does not promise a weight. Nothing here is a test and nothing is graded.
- Week 1Starting well: the titration window
Why the stomach and bowel side effects track your dose rather than arriving at random, and why the week after a dose goes up is the worst week to judge the whole treatment. What the trials actually reported, including the inconvenient numbers. Which of the standard nausea advice is evidence-backed and which is expert opinion: we tell you which is which rather than letting you find out later. The gallbladder, and why upper right abdominal pain is on the same-day list. And why your Whole Health Coach will decline a dose question every time, and what she will do instead.
- Week 2Eating when you are not hungry
The problem underneath the side effects: you are eating about a third less, and your requirements did not fall with your appetite. That flips the question from what to leave out to what to put in first, because you will run out of appetite before you run out of plate. The protein number, where it comes from, and what it rests on, which is research in people losing weight without these medications. What 25 to 35 g looks like in real food. Who the target does not apply to. And why fiber supplements are out here, even though the evidence for them in ordinary constipation is real.
- Week 3Starting to train
The resistance prescription, and the floor underneath it: one set per movement pattern, twice a week, about ten minutes, which is a real session and not a failed one. Why resistance work rather than walking alone, from a trial where every group lost the same weight and only the lifting groups kept the muscle and the bone. Joint-friendly substitutions offered by default, and the four things that stop a session. Two rules specific to your medication that are ours, not the literature's. And what you are actually training for right now, which is protecting rather than building.
- Week 4Holding the line
Module 1 closes with the thing most likely to end your treatment, which is not a side effect. It is cost, coverage or supply, and it arrives without warning. What the persistence studies actually show, including that they disagree with each other. The first 72 hours if your access changes, which is our clinical guidance and carries no citation because no research exists on it. And choosing your action number now, while it is still abstract, so a rise later prompts a conversation rather than a disappearance.
- Week 5What you are actually losing
Module 2 is called Protein and muscle, and it opens with the finding that explains why weeks 2 and 3 asked what they asked. About a quarter of what comes off is lean tissue, and the same is true of people losing weight on no medication at all: the split is what happens to a body losing weight rather than something the drug is doing to you. What changes is the absolute amount, because the total is roughly four times larger. Whether that loss is actually harmful is genuinely unsettled, and both sides of the argument are published, so you will not be handed a settled answer here. And why this pathway measures what your muscle does rather than estimating how much of it there is, which is the order the diagnostic frameworks themselves put things in.
- Week 6The protein number, and where it comes from
Week 2 gave you a number to hit. This week is where it came from, what it will and will not do, and why we ask for it three times a day rather than once a day. Why a per-meal target rather than a daily total, and the published figures the lower end of ours sits on. The ceiling, which is lower than the supplement aisle suggests. What protein does for fullness and what it does not do, which is change how much you eat at the next meal: we are not asking for it as an appetite tool, because the medication has already done that. The denominator problem, where none of the source papers says which body weight they mean and our answer is clinical judgment rather than a research finding. And the practical difficulty underneath all of it, which is volume rather than motivation.
- Week 7Training to hold, not to build
Week 3 gave you a training prescription. This week is what that training can and cannot achieve while you are on this medication, because the difference decides whether you read your own progress correctly. Strength goes up and muscle does not, and both of those come out of the same analysis: the energy deficit you are in prevents lean mass gains outright, and that is arithmetic about energy availability rather than anything about you. What to watch instead of the scale when your weight slows while your clothes keep changing. The progression order, repetitions before load and load before sets, which is ours rather than the literature's. The rules that end a session. And the honest gap: no trial has tested any of this in people taking these medications, so the best available answer is not a validated one.
- Week 8Measuring what matters
Week 8 closes Protein and muscle. It is a measurement week: nothing here is a test, nothing decides whether you continue, and none of it needs anything you do not already own. The four measures, and how to do them the same way you did them in week 0, which matters more than doing them precisely. Why function rather than a scan or a body-composition scale, and what we will not conclude from your numbers. What would count as a signal this early, and why everything unchanged is a good outcome at eight weeks rather than a null one. And why the questionnaires repeating at this boundary is the point rather than the paperwork.
Who you will work with
Your Whole Health Coach takes your first visit and closes every module, so it is the same person from the first session to the last. The specialists and clinicians below lead the weeks where their work is the focus.

Cindy is a Whole Health Coach with a background in clinical nursing and more than a decade of experience in healthcare. Her experience working closely with patients and multidisciplinary teams has given her a deep understanding of the many factors that contribute to overall health and well-being. Cindy believes that health is about more than any one diagnosis, symptom, or lab result.

Tonia is a Doctor of Physical Therapy, Integrative Nutrition Health Coach, and Certified McKenzie Spine Specialist with over 25 years of experience helping clients heal from pain, injury, and chronic conditions. She specializes in spine care, orthopedic rehabilitation, and restoring strength and vitality through personalized, science-based treatment.
What we work on
| Domain | What this pathway does |
|---|---|
| Nutrition & Metabolism | 25 to 35 g of protein at each of three eating occasions, which is the operative instruction. Behind it sits a range of 1.2 to 1.5 g per kg a day, measured against a reference weight rather than your actual one. The target is carried across from research on protecting muscle during weight loss generally: it has not been tested in people taking these medications. It does not apply if you have advanced kidney disease. |
| Movement & Mobility | Resistance training 2 sessions per week minimum, 3 preferred, all major muscle groups, 8 to 12 reps at roughly two reps in reserve. Progress reps before load, load before sets. Floor for a deconditioned member: one set per movement pattern, twice weekly, about 10 minutes, framed as the thing that counts. Train after the meal of the day you eat best, not fasted. In the difficult days after a dose increase, the floor session is the target rather than the full one. |
| Sleep & Recovery | Escalation weeks disturb sleep. Tracked, not treated as a separate problem. |
| Stress & Resilience | Appetite suppression removes a coping mechanism before anything replaces it. Named early rather than after a lapse. |
| Mind & Mood | PHQ-9 and GAD-7 at weeks 0, 4 and 8. Disordered eating screened at baseline: restriction, purging and secret eating are on the prompt escalation list. |
| Preventive care | Weight weekly if you want to, never daily, and never as the main measure. What this pathway reports back is function: strength, sit-to-stand and gait speed. |
How progress is measured
These are the validated tools this pathway uses: at your first visit, at the mid-program review, and at the end.
| Tool | Cadence | Owned by |
|---|---|---|
| Sit-to-stand, gait speed, grip | Wk 0, 4, 8 | Physical Therapy |
| Protein per meal, 3-day record | Wk 0 | Nutrition clinician |
| Resistance sessions completed | Weekly | Member + WHC |
| Weight | Weekly, opt-out | Member |
| PHQ-9 + GAD-7 | Wk 0, 4, 8 | WHC; LCSW reads |
| Access check: any change in supply or coverage | Every session | WHC |
The research behind this pathway
This pathway was built from the guidelines and studies below rather than from a clinician playbook. They are listed so you can read them yourself: every one is a real, published paper and the number at the end of each line is its PubMed ID.
Guidelines this pathway follows
- Nutritional priorities to support GLP-1 therapy for obesity · American College of Lifestyle Medicine, American Society for Nutrition, Obesity Medicine Association and The Obesity Society
The joint advisory this pathway is shaped around: managing side effects, preventing nutrient shortfalls when intake drops, and protecting muscle and bone with resistance training and enough protein. PMID 40445127
- Optimizing GLP-1 therapies for obesity and diabetes management · International Symposium on Diabetes and Nutrition working group
Where the protein and training targets come from. It is expert consensus rather than a trial result, and this pathway says so wherever it uses the numbers. PMID 41322078
- Definition and Diagnostic Criteria for Sarcopenic Obesity · ESPEN and EASO
Why this pathway measures what you can do, in strength and sit-to-stand, rather than reporting a muscle number it cannot measure. PMID 35196654
Key studies
- Wilding JPH et al. (2021). N Engl J MedOnce-Weekly Semaglutide in Adults with Overweight or Obesity
1,961 adults over 68 weeks. Average weight change was 14.9 percent against 2.4 percent on placebo, and nausea and diarrhea were the most common side effects: usually mild to moderate, and they settled with time. PMID 33567185
- Jastreboff AM et al. (2022). N Engl J MedTirzepatide Once Weekly for the Treatment of Obesity
2,539 adults over 72 weeks. This is the trial that shows the stomach and bowel side effects cluster in the dose-escalation period rather than lasting the whole program, which is why week 1 asks you to diary your dose changes. PMID 35658024
- Look M et al. (2025). Diabetes Obes MetabBody composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study of adults with obesity or overweight
160 people scanned at the start and at 72 weeks. About three quarters of the weight lost was fat and a quarter was lean tissue, and that split was the same on the medication as on placebo: what changes is how much, not the proportion. PMID 39996356
- Karakasis P et al. (2025). MetabolismEffect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis
22 trials pooled. Lean tissue accounted for roughly a quarter of the weight lost, which is the number behind everything this pathway does about protein and strength work. PMID 39719170
- Friedrichsen M et al. (2021). Diabetes Obes MetabThe effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity
At a test meal, people on the medication ate about 35 percent less. Your protein and vitamin needs do not fall by a third alongside it, and that gap is the whole reason week 2 exists. PMID 33269530
- Morton RW et al. (2018). Br J Sports MedA systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults
49 studies. More protein alongside strength training built more muscle and more strength, with no further gain above about 1.6 g per kg a day. That is the ceiling on the target this pathway gives you. PMID 28698222
- Villareal DT et al. (2017). N Engl J MedAerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults
160 older adults losing weight. Everyone lost about 9 percent, but the groups doing resistance work lost the least lean tissue and the least bone, and the combined group improved function most. PMID 28514618
- Lundgren JR et al. (2021). N Engl J MedHealthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined
195 adults over a year. Supervised exercise added to the medication roughly doubled the drop in body fat compared with either alone: the best evidence there is that training on top of the drug changes what you keep. PMID 33951361
- He L et al. (2022). JAMA Intern MedAssociation of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials
76 trials and 103,371 people. Gallbladder problems were more common on these medications, and more so again in the weight-loss trials, which is why upper right abdominal pain is on the same-day list rather than the wait-and-see one. PMID 35344001
- Gleason PP et al. (2024). J Manag Care Spec PharmReal-world persistence and adherence to glucagon-like peptide-1 receptor agonists among obese commercially insured adults without diabetes
Of 4,066 people who started outside a trial, 46.3 percent were still taking it at six months and 32.3 percent at a year. Weeks 1 to 12 are where that gets decided, which is why your sessions are weighted into them. PMID 38717042
- Aronne LJ et al. (2024). JAMAContinued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial
People who stopped the medication regained substantially, and diet and activity support carried on in both groups without preventing it. It is why this pathway promises habits, strength and early detection, and does not promise a weight. PMID 38078870
- Lincoff AM et al. (2023). N Engl J MedSemaglutide and Cardiovascular Outcomes in Obesity without Diabetes
17,604 people with existing heart disease followed for over three years. Serious heart events fell from 8.0 to 6.5 percent, and 16.6 percent stopped for side effects: the honest long-horizon figure on both benefit and tolerability. PMID 37952131

